Details
| Name | SIRT1 |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | endothelial tissue |
| Experiment Method | Cell proliferation assay, Western blot |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | Furthermore, pretreatment with paeonol significantly decreased the levels of p53, acetyl H3K14 and H4K16 protein expression upregulated by H2O2 stimulation.The changes in the histone protein levels were accompanied with an increase in Sirt1 protein expres |
| Regulation Gene | p53 |
| Year | 2014 |
| Pubmed ID | 24768807 |
| Title | Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway. |
| Drug | paeonol |
| Disease | NA |
| Environment Factors | H2O2 |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |