A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SIRT1
Type histone modification
Species Homo sapiens
Tissue Muscle
Experiment Method PCR, Western blot, Immunofluorescence
Up/Down Down
Pro/Anti Pro
Funtion Description We studied SIRT1 in an aging-associated muscle disease, sporadic inclusion-body myositis (s-IBM), whose muscle fibers contain increased NF-kappaB activation and abnormal accumulation of Abeta.We propose that in s-IBM muscle fibers, inadequate activity
Regulation Gene SIRT1
Year 2008
Pubmed ID 18922603
Title Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers
Drug NA
Disease sporadic inclusion-body myositis (s-IBM)
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA