| Name |
SIRT6
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
Human 293T and U2OS cell lines (ATCC)
|
| Experiment Method |
Histone deacetylation assays and mass spectrometry,Immunofluorescence,Co-immunoprecipitation,Chromatin immunoprecipitation (ChIP),ChIP-sequencing and computational analysis,RT-PCR,Senescence-associated B-galactosidase assay,Northern blot
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
At pericentric heterochromatin, SIRT6 promotes deacetylation of a new substrate, residue K18 of histone H3 (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts. Strikingly, deplet
|
| Regulation Gene |
SIRT6
|
| Year |
2016
|
| Pubmed ID |
27043296
|
| Title |
SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|