Details
| Name | SIRT6 |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | bone samples |
| Experiment Method | ChIP;Western Blotting;qPCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | We show that SIRT6 deficiency in mice produces low-turnover osteopenia caused by impaired bone formation and bone resorption, which are mechanisms similar to those of age-related bone loss. In addition, SIRT6 deficiency produces hyperacetylation of H3K9 i |
| Regulation Gene | H3K9 |
| Year | 2015 |
| Pubmed ID | 26189760 |
| Title | SIRT6 Deficiency Culminates in Low-Turnover Osteopenia |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |