| Name |
SIRT6
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
heart, aortic
|
| Experiment Method |
RT-PCR, Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
ICA upregulated the expression of SIRT6 and had an inhibitory effect on NF-kB (p65) inflammatory signaling pathways by decreasing the mRNA levels of NF-kB (p65) downstream target genes TNF-a, ICAM-1, IL-2, and IL-6. Those effects were mediated directly or
|
| Regulation Gene |
NF-kB (p65), TNF-a, ICAM-1, IL-2, IL-6
|
| Year |
2015
|
| Pubmed ID |
25688369
|
| Title |
Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway.
|
| Drug |
icariin (ICA)
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|