| Name |
SIRT6
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
lung
|
| Experiment Method |
PCR, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
CS extract (CSE) suppressed SIRT6 expression in HBECs. CSE-induced HBEC senescence was inhibited by SIRT6 overexpression, whereas SIRT6 knockdown and mutant SIRT6 (H133Y) without histone deacetylase activity enhanced HBEC senescence. SIRT6 overexpress
|
| Regulation Gene |
SIRT6, ATG5, LC3B, p21
|
| Year |
2014
|
| Pubmed ID |
24367027
|
| Title |
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
smoking
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|