| Name |
SIRT6
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
vessel
|
| Experiment Method |
PCR, RNAi, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
SIRT6 depletion by RNA interference in human umbilical vein endothelial cells (HUVEC) and aortic endothelial cells reduced cell proliferation, increased the fraction of senescence-associated-B-galactosidase-positive cells, and diminished the ability
|
| Regulation Gene |
p21, ICAM-1, PAI-1
|
| Year |
2013
|
| Pubmed ID |
23201774
|
| Title |
SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|