| Name |
SIRT6
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
bronchia
|
| Experiment Method |
PCR, Flow cytometry assay, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
We found that TGF-B induced senescence in primary HBEC by increasing p21 expression, and, whereas TGF-B also induced SIRT6, it was not sufficient to inhibit cellular senescence. However, overexpression of SIRT6 efficiently inhibited TGF-B-induced sene
|
| Regulation Gene |
p21
|
| Year |
2011
|
| Pubmed ID |
21224216
|
| Title |
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-B-induced senescence of human bronchial epithelial cells.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|