| Name |
SUV39H1
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
qRT-PCR, ChiP, Flow cytometry assay, Western blot, pulldown assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
we propose a role of the downregulation of SUV39H1 expression, a histone methyltransferase that specifically trimethylates H3K9, and the corresponding reduction in H3K9me3 levels in the establishment of IR-induced senescence.
|
| Regulation Gene |
SUV39H1, p53
|
| Year |
2015
|
| Pubmed ID |
25484892
|
| Title |
SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
X-ray
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|