| Name |
WAF1
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
human neuroblastoma SKN-SH and glioma U251 cell lines
|
| Experiment Method |
ChIP,qPCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Chromatin immunoprecipitation experiments indicated that doxorubicin was able to induce acetylation of histone H3 at the promoter of p21/WAF1 only at senescence-inducing concentrations.
|
| Regulation Gene |
WAF1
|
| Year |
2006
|
| Pubmed ID |
16557274
|
| Title |
The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis
|
| Drug |
doxorubicin
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|