| Name |
XRCC1
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
skin
|
| Experiment Method |
Cell proliferation assay, Western blot, Immunofluorescence analysis
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
DDR with checkpoint activation was indicated by histone H2AX and Chk2 protein phosphorylation, and by increased p53 protein levels. These findings occurred in concomitance with increased levels of phosphorylated XRCC1 detected in DS cells. These res
|
| Regulation Gene |
p53
|
| Year |
2015
|
| Pubmed ID |
26258283
|
| Title |
Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts.
|
| Drug |
0
|
| Disease |
Down syndrome
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|