Details
| Name | ZMPSTE24 |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | qRT-PCR, Western blot |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Zmpste24-deficient mice show a hypermethylation of rDNA that reduces the transcription of ribosomal genes, being this reduction reversible upon treatment with DNA methyltransferase inhibitors, This alteration has been previously described during physi |
| Regulation Gene | Elovl3, Cmah |
| Year | 2010 |
| Pubmed ID | 20961378 |
| Title | Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. |
| Drug | azacitidine |
| Disease | Hutchinson-Gilford progeria syndrome |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |