| Name |
ANRIL
|
| Type |
lncRNA
|
| Species |
Homo sapiens
|
| Tissue |
vascular
|
| Experiment Method |
qRT-PCR,Western blot,SenescenceassociatedBgalactosidase (SABgal) assay,Dual luciferase reporter assay
|
| Up/Down |
Down
|
| Pro/Anti |
anti
|
| Funtion Description |
ANRIL could promote cell viability and inhibit senescence of VSMCs possibly by regulating miR-181a/Sirt1, and alleviate cell cycle arrest by inhibiting p53/p21 pathway.
|
| Regulation Gene |
miR-181a / Sirt1
|
| Year |
2019
|
| Pubmed ID |
30789795
|
| Title |
LncRNA-ANRIL inhibits cell senescence of vascular smooth muscle cells by regulating miR-181a/Sirt1.
|
| Drug |
NA
|
| Disease |
Cardiovascular disease
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|