| Name |
H19
|
| Type |
lncRNA
|
| Species |
Homo sapiens
|
| Tissue |
Lumbar disc
|
| Experiment Method |
Senescence assay (SA-B-gal staining), RT-PCR. Immunofluorescence staining,Luciferase reporter assays
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
H19 could accelerate H2O2-induced degenerative changes by promoting cell senescence, increasing ADAMTS-5 and MMPs protein levels and Collagen I content, as well as suppressing NPC proliferation through activating Wnt/B-catenin signaling.
|
| Regulation Gene |
miR-22
|
| Year |
2018
|
| Pubmed ID |
29520849
|
| Title |
LncRNA H19 targets miR-22 to modulate H2 O2 -induced deregulation in nucleus pulposus cell senescence, proliferation, and ECM synthesis through Wnt signaling.
|
| Drug |
H2O2
|
| Disease |
NA
|
| Environment Factors |
oxidation
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|