| Name |
TUG1
|
| Type |
lncRNA
|
| Species |
Homo sapiens
|
| Tissue |
NP
|
| Experiment Method |
qRT-PCR,Western blot,TUNEL, SA-b-gal staining,ELISA
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
TUG1 siRNA may inhibit Wnt/b-catenin signaling pathway to prevent the apoptosis and senescence, elevate the proliferation, and improve the imbalance in ECM metabolism of the TNF-a-induced human NPCs, which provided a scientific basis for the clinical trea
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28756222
|
| Title |
Role of LncRNA TUG1 in intervertebral disc degeneration and nucleus pulposus cells via regulating Wnt/B-catenin signaling pathway.
|
| Drug |
TNF-a
|
| Disease |
intervertebral disc degeneration
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|