Details
| Name | ARF promoter |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | neonatal human foreskins cell |
| Experiment Method | Western Blotting,qPCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | ARF was methylated in c-Myc-immortalized but not early-passage c-Myc-expressing cells, indicating that methylation of ARF was an event that occurred during selection of the immortalized population. In contrast, p16 was unmethylated in both early-passage a |
| Regulation Gene | ARF |
| Year | 2007 |
| Pubmed ID | 17982115 |
| Title | Epigenetic down-regulation of ARF expression is a selection step in immortalization of human fibroblasts by c-Myc |
| Drug | NA |
| Disease | immortalize human cells |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |