| Name |
BKB1
|
| Type |
methylation
|
| Species |
Mus musculus
|
| Tissue |
mesenteric arteries
|
| Experiment Method |
Western blot, DNA bisulfite sequencing PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
aging triggered an increase in BKB1 promoter methylation in both old WKY andSHR, with concomitant suppression of theB1 subunit and BKCachannel activity. Consistently, hypertension decreased CpG methylation of the BKB1 promoter at all ages.
|
| Regulation Gene |
BKB1
|
| Year |
2017
|
| Pubmed ID |
29093563
|
| Title |
BKCa channel activity and vascular contractility alterations with hypertension and aging via B1 subunit promoter methylation in mesenteric arteries.
|
| Drug |
0
|
| Disease |
hypertension
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|