| Name |
CHD5 promoter
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
Liver
|
| Experiment Method |
PCR, Cell proliferation assay, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
CHD5 expression was sinificantly down-regulated in HCC cell lines and tissues examined, and the -841 to -470 region of CHD5 promoter was hypermethylated in these samples. Treatment with DNA methyltransferase inhibitor 5-aza-2-deoxycytidine resulted in
|
| Regulation Gene |
CHD5
|
| Year |
2014
|
| Pubmed ID |
24529164
|
| Title |
CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma.
|
| Drug |
5-aza-2-deoxycytidine
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|