| Name |
BMAL1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
bone
|
| Experiment Method |
PCR, Flow cytometry assay, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Bmal1 deletion in joint mesenchymal cells rendered the FLS and articular cartilage cells arrhythmic. Loss of Bmal1 in FLS rendered these resident immune cells more pro-inflammatory in response to challenge, leading to increased paw swelling, localised inf
|
| Regulation Gene |
NA
|
| Year |
2019
|
| Pubmed ID |
30612576
|
| Title |
The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis
|
| Drug |
0
|
| Disease |
inflammatory arthritis
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
NA
|
| High-throughput |
NA
|