| Name |
GPX7 promoter
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
oesophagus
|
| Experiment Method |
PCR, Flow cytometry assay, Cell proliferation assay, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
GPX7-expressing cells displayed significant impairment in G1/S progression and an increase in cell senescence. We confirmed the tumour suppressor function in vivo using GPX7-expressing OE33 cells in a mouse xenograft model. Pyrosequencing of the GPX7 p
|
| Regulation Gene |
GPX7, p73, p27, p21, p16, RB
|
| Year |
2013
|
| Pubmed ID |
23580780
|
| Title |
Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.
|
| Drug |
0
|
| Disease |
oesophageal adenocarcinomas (OAC)
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|