A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name hTERT promoter
Type methylation
Species Homo sapiens
Tissue normal oral fibroblasts and senescent normal oral keratinocytes
Experiment Method qPCR
Up/Down Up
Pro/Anti Pro
Funtion Description The expression of hTERT mRNA diminished in senescent NHOK, but was not detected in NHOF at any stage of replication. An exogenous hTERT promoter was active in NHOF and in senescing NHOK, indicating that the lack of hTERT gene expression resulted from alte
Regulation Gene hTERT
Year 2003
Pubmed ID 14562019
Title Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA