| Name |
IGF2
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
Samples of normal colon were obtained at surgical resection from a group of patients with nonneoplastic diseases of the colon. Normal lymphocytes and bone marrow cells were obtained from healthy donors of bone marrow for transplantation. All other samples
|
| Experiment Method |
Southern Blots;Allele-Specific Methylation Assay;Reverse Transcription-PCR;
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
In young individuals, the P2-4 promoters of IGF2 are methylated exclusively on the silenced maternal allele. During aging, this promoter methylation becomes more extensive and involves the originally unmethylated allele. In tumors, this methylation is ass
|
| Regulation Gene |
IGF2
|
| Year |
1996
|
| Pubmed ID |
8876210
|
| Title |
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|