Details
| Name | IL-1B |
| Type | methylation |
| Species | Mus musculus |
| Tissue | brain |
| Experiment Method | qRT-pCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Novel findings indicated that aged mice had decreased methylation of the IL-1B gene promoter in primary microglia basally or following systemic LPS that is associated with increased IL-1B mRNA, intracellular IL-1B production, as well as prolonged sickness |
| Regulation Gene | IL-1B |
| Year | 2016 |
| Pubmed ID | 27500965 |
| Title | Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1B promoter DNA methylation in microglia. |
| Drug | 5-aza |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |