Details
| Name | IRF5 |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | RT-PCR |
| Up/Down | differential expression |
| Pro/Anti | Pro |
| Funtion Description | the epigenetic inactivation of the IFN pathway plays a critical role in cellular immortalization, and the reactivation of IFN- regulated genes by transcription factors IRF5 and/or IRF7 is sufficient to induce cellular senescence. |
| Regulation Gene | IRF5 |
| Year | 2008 |
| Pubmed ID | 18505922 |
| Title | Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |