| Name |
Kl
|
| Type |
methylation
|
| Species |
Mus musculus
|
| Tissue |
kidney
|
| Experiment Method |
DNA demethylase assay, qRT-PCR, Western blot,
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Klotho(KL) is described as an anti-aging gene because mutation of Kl gene leads to multiple pre-mature aging phenotypes and shortens lifespan in mice. We found that Compound H increased Kl expression via demethylation in CpG islands of the Kl gene.
|
| Regulation Gene |
Kl
|
| Year |
2017
|
| Pubmed ID |
28657902
|
| Title |
Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands.
|
| Drug |
N-(2-chlorophenyl)-1H-indole-3-caboxamide
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|