Details
| Name | klotho |
| Type | methylation |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | Western blot,RT-PCR |
| Up/Down | Down |
| Pro/Anti | NA |
| Funtion Description | Compound H abolished aging-associated downregulation of secreted Klotho (SKL) levels in both kidneys and serum likely by enhancing DNA demethylase activity and decreasing DNA methylation. |
| Regulation Gene | Klotho |
| Year | 2018 |
| Pubmed ID | 29659128 |
| Title | Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension. |
| Drug | NA |
| Disease | hypertension |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |