| Name |
BRCA1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
mouse embryonic fibroblasts
|
| Experiment Method |
immunoblotting
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here we provide evidence to support this theory by showing that the absence of the Brca1 full-length isoform causes senescence in mutant embryos and cultured cells as well as aging and tumorigenesis in adult mice.
|
| Regulation Gene |
NA
|
| Year |
2003
|
| Pubmed ID |
12533509
|
| Title |
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|