| Name |
Lgr5
|
| Type |
methylation
|
| Species |
Mus musculus
|
| Tissue |
intestinal epithelial organoids
|
| Experiment Method |
RT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
accumulation of senescence-associated B-galactosidase and up-regulation of Cdkn1a (p21) by DNA demethylation were observed in intestinal epithelial organoids derived from aged mice.
|
| Regulation Gene |
Cdkn1a
|
| Year |
2019
|
| Pubmed ID |
30534415
|
| Title |
Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE103634
|