| Name |
BRG1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Bone marrow
|
| Experiment Method |
Western blotting;Immunocytochemistry;Senescence-associated b-galactosidase assay;reverse transcriptase-PCR and real-time PCR;TUNEL assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Knockdown of BRG1 expression induced a significant increase in senescent cells and decrease in apoptotic cells.It is interesting that BRG1 downregulation also induced an increase in heterochromatin. At the molecular level, these phenomena were associated
|
| Regulation Gene |
NA
|
| Year |
2010
|
| Pubmed ID |
20697355
|
| Title |
The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|