Details
| Name | NEP promoter |
| Type | methylation |
| Species | Mus musculus |
| Tissue | brain |
| Experiment Method | PCR, Western blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Neprilysin (NEP) is one of the enzymes responsible for Abeta degradation, with its expression decreasing in both Alzheimer and aging brains.We find that Abeta reduces global DNA methylation whilst increasing NEP DNA methylation and further suppressing t |
| Regulation Gene | NEP |
| Year | 2008 |
| Pubmed ID | 19007750 |
| Title | The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. |
| Drug | AzaC |
| Disease | Alzheimer's disease |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |