| Name |
OP-1 promoter
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
bone
|
| Experiment Method |
PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Age-related methylation of the OP-1 promoter may contribute to a decrease in OP-1 production in cartilage and a decrease in expression of OP-1 responsive genes such as IGF-1, the IGF-1R, and aggrecan.
|
| Regulation Gene |
IGF-1, IGF-1R, aggrecan, OP-1
|
| Year |
2008
|
| Pubmed ID |
18829350
|
| Title |
Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage
|
| Drug |
5-azacytidine
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|