Details
| Name | p16 |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | breast |
| Experiment Method | qRT-PCR |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | In this article, we reported that disruption of Brca1 in the mammary epithelium resulted in premature senescence that was rescued by p16 loss. We discovered that promoter methylation silenced p16 expression in most of the tumors developed in mice heterozy |
| Regulation Gene | p16 |
| Year | 2016 |
| Pubmed ID | 27811360 |
| Title | p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. |
| Drug | 0 |
| Disease | breast cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |