| Name |
p16 promoter
|
| Type |
methylation
|
| Species |
Syrian hamster
|
| Tissue |
Syrian hamster embryo-derived (SHE) cells
|
| Experiment Method |
qRT-PCR,Sanger sequencing,bisulfite-sequencing,Senescence-associated beta-galactosidase staining
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Expression of p16 was commonly silenced or markedly reduced with extensive promoter methylation observed in 45% of MT clones, while Bmi1 was strongly upregulated in 25% of clones. In instances where secondary events to MT appeared necessary for senescence
|
| Regulation Gene |
p16
|
| Year |
2016
|
| Pubmed ID |
27169376
|
| Title |
A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|