Details
| Name | p16(INK4a) promoter |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | skin |
| Experiment Method | RT-PCR, Western blot |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Our results indicate that the ROS-induced cellular senescence in NHEKs was caused by the upregulation p16(INK4a) through demethylation in its promoter region, which is not detected in SCCs, suggesting that ROS-induced cellular senescence contributes to tu |
| Regulation Gene | p16(INK4a) |
| Year | 2014 |
| Pubmed ID | 25181340 |
| Title | Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16(INK4a.). |
| Drug | 0 |
| Disease | squamous carcinoma |
| Environment Factors | Reactive oxygen species (ROS) |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |