| Name |
p16INK4a
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
Human adenoid epithelial cells (HAKs) and human foreskin keratinocytes (HFKs)
|
| Experiment Method |
Northern Blot;Western and Immunohistochemical Analyses;Bisulfite-PCR;bisulfite methylation analysis
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Interestingly, treatment with azadeoxycytidine and concomitant up-regulation of p16INK4a or p14ARF caused a senescent-like phenotype, as measured by B-galactosidase staining and morphological alteration, in all of the cell lines tested (data not shown). H
|
| Regulation Gene |
p16INK4a
|
| Year |
2000
|
| Pubmed ID |
10793065
|
| Title |
Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by Telomerase
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|