Details
| Name | p16INK4a exon 1 |
| Type | methylation |
| Species | Mus musculus |
| Tissue | gastrointestinal tract |
| Experiment Method | qRT-PCR, Western blot |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | hyperplastic crypts remain dormant for prolonged periods due to the induction of crypt senescence accompanied by upregulation of senescence-associated B-galactosidase and p16(Ink4a). We show that tumour progression is associated with down-regulation of |
| Regulation Gene | p16, Cdkn2a |
| Year | 2010 |
| Pubmed ID | 20941790 |
| Title | V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. |
| Drug | PD184352 |
| Disease | colorectal cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |