| Name |
p16INK4A promoter
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
human mesenchymal stem cells
|
| Experiment Method |
Bisulfite Sequencing,qPCR
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
Most of the p16INK4A-positive cells were Ki67-negative and senescence associated beta-galactosidase-positive, and the suppression of p16INK4A gene expression by small interfering RNA in senescent hMSCs reduced the number of senescent cells and endowed the
|
| Regulation Gene |
p16INK4A
|
| Year |
2007
|
| Pubmed ID |
17569790
|
| Title |
Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|