Details
| Name | p16S140A |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | cell lines (293T and WI-38) |
| Experiment Method | Western blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Compared to wild type p16, mutant p16R138K possessed improved function in preventing cell proliferation and inducing apoptosis, while the Ser 140 mutation (p16S140A) exhibited the opposite alteration. Furthermore, the elevated arginine methylation in p16S |
| Regulation Gene | p16 |
| Year | 2017 |
| Pubmed ID | 28120917 |
| Title | The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence. |
| Drug | H2O2 |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |