Details
| Name | p21 |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | qRT-pCR, ChIP |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Enrichment of both EZH2 and H3K27me3 levels in the p21 promoter region is reduced by LDM. Moreover, EZH2 overexpression reduces cellular senescence, p21 expression and DNA damage response upon LDM exposure. |
| Regulation Gene | p21 |
| Year | 2016 |
| Pubmed ID | 27882937 |
| Title | EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells. |
| Drug | Lidamycin |
| Disease | colon cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |