| Name |
p21 promoter
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
human embryonic lung diploid fibroblast 2BS cell
|
| Experiment Method |
Bisulfite Sequencing,qPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We show that p21(Waf1/Cip1) and p16(INK4a) have different methylation patterns during the aging process of normal human 2BS and WI-38 fibroblasts. p21(Waf1/Cip1) promoter is gradually methylated up into middle-aged fibroblasts but not with senescent fibro
|
| Regulation Gene |
p21
|
| Year |
2006
|
| Pubmed ID |
16514663
|
| Title |
p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|