| Name |
PDE4D4
|
| Type |
methylation
|
| Species |
Rat Rattus
|
| Tissue |
prostate cancer cells
|
| Experiment Method |
Bisulfite Sequencing,qPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Early and prolonged hypomethylation at this site following neonatal estradiol or bisphenol A exposure resulted in continued, elevated PDE4D4 expression. Cell line studies confirmed that site-specific methylation is involved in transcriptional silencing of
|
| Regulation Gene |
PDE4D4
|
| Year |
2006
|
| Pubmed ID |
16740699
|
| Title |
Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
|
| Drug |
NA
|
| Disease |
prostate cancer
|
| Environment Factors |
neonatal estradiol or bisphenol A exposure
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|