| Name |
POLD1
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
RTPCR,western blot,ChIP,BSP
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
the attenuation of the binding affinity of E2F1 for the POLD1 promoter, mediated by an age-related decline in E2F1 and increased methylation of CpG island 3, downregulates POLD1 expression in aging.
|
| Regulation Gene |
POLD1,E2F1
|
| Year |
2019
|
| Pubmed ID |
30895337
|
| Title |
E2F1 mediates the downregulation of POLD1 in replicative senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
NA
|
| High-throughput |
NA
|