Details
| Name | PRMT5 |
| Type | methylation |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | RT-PCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | PRMT5 knockdown in GBMDC led to apoptosis, knockdown in GBMNS led to G1 cell cycle arrest through upregulation of p27 and hypophoshorylation of retinoblastoma protein, leading to senescence. |
| Regulation Gene | PRMT5 |
| Year | 2017 |
| Pubmed ID | 27292259 |
| Title | PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. |
| Drug | NA |
| Disease | glioblastoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |