A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name RARB1 promoter
Type methylation
Species Homo sapiens
Tissue normal adult colon tissues
Experiment Method qPCR
Up/Down Down
Pro/Anti Pro
Funtion Description Methylation of RARbeta1 was detected, with a mean of 2% in normal colon tissues in young subjects (< 32 years), and 16% in older subjects (> 75 years) (P < 0.001). We suggest that the embryonic RARbeta1 isoform is readily hypermethylated in aging colon mu
Regulation Gene RARbeta1
Year 2004
Pubmed ID 14726683
Title Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer
Drug NA
Disease colorectal cancer
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA