| Name |
rDNA
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
Normal human fibroblast cultures GM08429 (1-day old donor) and GM08447 (2-day old donor);The WS primary fibroblast cultures (AG03141 and AG00780) and additional normal human fibroblast cultures AG11744 (84-year old donor) and AG05247 (87-year old donor)
|
| Experiment Method |
Southern blotting and hybridizations
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
the rDNA species observed in this study were longer, linear rDNA molecules attributable to the inhibition of ECO:RI cleavage by methylation. in vitro senescence of fibroblasts is accompanied by significant increases in cytosine methylation within rDNA gen
|
| Regulation Gene |
NA
|
| Year |
2000
|
| Pubmed ID |
10973920
|
| Title |
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts.
|
| Drug |
NA
|
| Disease |
Werner syndrome
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|