| Name |
SEC27
|
| Type |
methylation
|
| Species |
Saccharomyces cerevisiae
|
| Tissue |
NA
|
| Experiment Method |
RNA-seq, PCR, ChiP, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Our results reveal that lack of sustained histone H3K36 methylation is commensurate with increased cryptic transcription in a subset of genes in old cells and with shorter life span. In contrast, deletion of the K36me2/3 demethylase Rph1 increases H3K36me
|
| Regulation Gene |
SEC63, TRP5, SEC27
|
| Year |
2015
|
| Pubmed ID |
26159996
|
| Title |
H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
1
|
| High-throughput |
GSE65767
|