| Name |
SHC
|
| Type |
methylation
|
| Species |
Homo sapiens
|
| Tissue |
Human umbilical vein endothelial cells (HUVECs)
|
| Experiment Method |
RT-qPCR analysis,reporter gene assays,Bisulfate RNA sequencing,Western blot analysis
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells
|
| Regulation Gene |
SHC
|
| Year |
2016
|
| Pubmed ID |
26992231
|
| Title |
RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|