| Name |
SOX1 promoter
|
| Type |
methylation
|
| Species |
Mus musculus
|
| Tissue |
Liver
|
| Experiment Method |
PCR, Luciferase reporter assay, Flow cytometry assay, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
In this study, we confirmed via quantitative methylation-specific polymerase chain reaction that SOX1 was frequently downregulated through promoter hypermethylation in HCC cells and tissues. Overexpression of SOX1 by a constitutive or inducible approac
|
| Regulation Gene |
SOX1, p21, p27
|
| Year |
2012
|
| Pubmed ID |
22767186
|
| Title |
SOX1 functions as a tumor suppressor by antagonizing the WNT/B-catenin signaling pathway in hepatocellular carcinoma.
|
| Drug |
doxorubicin
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|