Details
| Name | ZEB1 |
| Type | methylation |
| Species | Homo sapiens |
| Tissue | skin |
| Experiment Method | qRT-PCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | down-regulation of ZEB1 caused by UVA induced ROS could transcriptionally inhibit DNMT1, leading to low methylation level of senescence related proteins p53 and increase its expression, eventually result in cellar senescence. |
| Regulation Gene | p53 |
| Year | 2018 |
| Pubmed ID | 29466247 |
| Title | Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |