| Name |
let-7
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
neural stem cell
|
| Experiment Method |
Immunocytochemistry, immunohistochemistry, western blots, qRT-PCR, and ChIP
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16(Ink4a). We discovered that the Hmga2 transcriptional
|
| Regulation Gene |
NA
|
| Year |
2008
|
| Pubmed ID |
18957199
|
| Title |
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|